BIOT 250 - Principles of Biomanufacturing

(G only)

An introduction to the process of producing a biological product using a cell line. The course will be organized as a production campaign in a simulated cGMP environment. Students will complete a batch record as they produce a biological product. Emphasis will be on upstream and downstream processes. Hands-on laboratory work will involve the preparation and qualification of growth media and chromatography buffers, the use of bioreactors and FPLC protein purification systems. The role of QA/QC will be discussed. PREREQUISITE(S): BIOT 120 ; BIOT 200 or consent of department. Three hours lecture, three hours laboratory each week. Formerly BT 235.

4 semester hours

Course Outcomes:
Upon course completion, a student will be able to:

Define the elements of cGMP.
Explain upstream processing.
Explain downstream processing.
Assemble and run growth vessels for insect or mammalian cells.
Assemble and run protein purification equipment.

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